Form and Function of Connectives in Chinese Conversational Speech

Connectives convey discourse functions that provide textual and pragmatic information in speech communication on top of canonical, sentential use. This paper proposes an applicable scheme with illustrative examples for distinguishing Sentential, Conclusion, Disfluency, Elaboration, and Resumption uses of Mandarin connectives, including conjunctions and adverbs. Quantitative results of our annotation works are presented to gain an overview of connectives in a Mandarin conversational speech corpus. A fine-grained taxonomy is also discussed, but it requires more empirical data to approve the applicability. By conducting a multinomial logistic regression model, we illustrate that connectives exhibit consistent patterns in positional, phonetic, and contextual features oriented to the associated discourse functions. Our results confirm that the position of Conclusion and Resumption connectives orient more to positions in semantically, rather than prosodically, determined units. We also found that connectives used for all four discourse functions tend to have a higher initial F0 value than those of sentential use. Resumption and Disfluency uses are expected to have the largest increase in initial F0 value, followed by Conclusion and Elaboration uses. Durational cues of the preceding context enable distinguishing Sentential use from discourse uses of Conclusion, Elaboration, and Resumption of connectives

Pengembangan Suplemen Pembelajaran Fisika Gelombang Elektromagnetik Cahaya Sebagai Partikel Memanfaatkan Virtual Laboratorium

This research has been done to make a supplement for physics learning about light electromagnetic wave as a particle using virtual laboratory. The population of this research was the second year science-students at SMA Muhammadiyah 1 Metro. This development is begun by needs analysis, then identification of resource which is the background of this developmental research. The next step is, identifying the product specification then developing products which contained a tutorial book for teacher and a work sheet for student (LKS). The material and design expert test result is that those products were approved. The external test resulted by users show that the LKS was attractive, very easy to use, and useful. It also was effective to be used as a learning resource because 80% of students reached the passing grade.Telah dilakukan penelitian untuk mengembangkan suplemen pembelajaran fisika gelombang elektromagnetik cahaya sebagai partikel dengan memanfaatkan virtual laboratorium. Populasi penelitian pengembangan ini adalah siswa kelas XI IPA di SMA Muhammadiyah 1 Metro. Pengembangan ini diawali dengan analisis kebutuhan, kemudian identifikasi sumber daya yang melatar belakangi pengembangan. Langkah selanjutnya identifikasi spesifikasi produk yang dilanjutkan dengan mengembangkan produk berupa LKS untuk siswa dan buku panduan untuk guru. Hasil uji internal oleh ahli materi dan ahli desain menyatakan produk yang dikembangkan layak digunakan sebagai media pembelajaran. Hasil uji eksternal oleh pengguna menunjukkan kualitas media pembelajaran menarik, sangat mudah digunakan, dan bermanfaat serta efektif digunakan sebagai media pembelajaran dengan presentase hasil belajar sebesar 80% siswa telah memenuhi KKM

Executive Master of Business Administration Cross-Strait Program, College of Management, National Chi Nan University

[[abstract]]摘要 本研究程序首先經由研究者的實務經驗，針對現在產業概況的統整與提問，確立研究主題、背景與動機、研究目的，並經由國內外相關的探討並從相關理論與研究實證探討中，挑選與確認研究方法，接者考量個案公司面臨之經濟情形，以及其組織內在狀況，面臨之外在環境變化，確認台灣「工業4.0」過去、現在發展的一切，盡量收集與已經發表之資料為研究範圍。並進而選定台灣「工業4.0」發展過程中智慧製造業務之不同利益關係對象涵蓋推動單位(經濟部)、執行單位（機械產業界、個案公司之高階經理人、中階專業主管與低階從業人員)，與學著專家等為受訪研究對象。 最後，研究者與指導老師共同交換意見並確定訪談問題與實施方式，相繼進行當面現地訪談個別研究對象以收集研究分析資料，後續並對資料解讀與分析，最後依序回答研究目的設定之問題，並不斷重複提問，以獲得本研究合理與滿意之結論與建議。[[abstract]]Abstract The research process firstly establishes the research theme, background, motivation, and research purpose through the practical experiences of the researcher. The study aims at the integration and questioning of the current industrial profile. It also selects relevant researches at home and abroad and empirically studies the relevant theories and researches. In addition to confirming the research method, the researcher considers the economic situation facing the company and the internal conditions of the organization, and changes existing in the external environment. It confirms all the past and current developments in Taiwan’s “Industry 4.0” and tries to collect and publish the published data as research. Furthermore, the research chose the different interests of the Taiwanese manufacturing industry in the “Industry 4.0” development target including the promotion unit (Ministry of Economic Affairs), executive units (high-level managers , middle-level professional managers, and low-level employees in the case company of machinery industry ), and scholars and experts were also interviewed for the study. Finally, the researcher exchanged opinions with the instructors to determine the interview questions and implementation methods, and thus conducted individual interviews with study selected subjects to gather research and analysis data, followed by interpretation and analysis of the text data, and finally answered the questions set in the study objectives. Repeatedly asked questions were applied to obtain the conclusions and recommendations reasonable and satisfactory to this study.[[note]]碩

Mindfulness Training Enhances Endurance Performance and Executive Functions in Athletes: An Event-Related Potential Study

Mindfulness interventions have been linked to improved sport performance and executive functions; however, few studies have explored the effects of mindfulness on sport performance and executive functions simultaneously. This study sought to examine whether a mindfulness training program would affect both the endurance performance and executive functions of athletes. In addition, event-related potentials (ERPs) associated with the Stroop task were assessed to investigate the potential electrophysiological activation associated with the mindfulness training. Applying a quasiexperimental design, forty-six university athletes were recruited and assigned into a five-week mindfulness training program or a waiting list control group. For each participant, the mindfulness level, endurance performance assessed by a graded exercise test, executive functions assessed via Stroop task, and N2 component of ERPs were measured prior to and following the 5-week intervention. After adjusting for the preintervention scores as a covariate, it was found that the postintervention mindfulness level, exhaustion time, and Stroop task accuracy scores, regardless of task condition, of the mindfulness group were higher than those of the control group. The mindfulness group also exhibited a smaller N2 amplitude than the control group. These results suggest that the five-week mindfulness program can enhance the mindfulness level, endurance performance, and multiple cognitive functions, including executive functions, of university athletes. Mindfulness training may also reduce conflict monitoring in neural processes

Biosensing Amplification by Hybridization Chain Reaction on Phase-Sensitive Surface Plasmon Resonance

Surface Plasmon Resonance (SPR) is widely used in biological and chemical sensing with fascinating properties. However, the application of SPR to detect trace targets is hampered by non-specific binding and poor signal. A variety of approaches for amplification have been explored to overcome this deficiency including DNA aptamers as versatile target detection tools. Hybridization chain reaction (HCR) is a high-efficiency enzyme-free DNA amplification method operated at room temperature, in which two stable species of DNA hairpins coexist in solution until the introduction of the initiator strand triggers a cascade of hybridization events. At an optimal salt condition, as the concentrations of H1 and H2 increased, the HCR signals were enhanced, leading to signal amplification reaching up to 6.5-fold of the detection measure at 30 min. This feature enables DNA to act as an amplifying transducer for biosensing applications to provide an enzyme-free alternative that can easily detect complex DNA sequences. Improvement of more diverse recognition events can be achieved by integrating HCR with a phase-sensitive SPR (pSPR)-tested aptamer stimulus. This work seeks to establish pSPR aptamer system for highly informative sensing by means of an amplification HCR. Thus, combining pSPR and HCR technologies provide an expandable platform for sensitive biosensing

Biosensing Amplification by Hybridization Chain Reaction on Phase-Sensitive Surface Plasmon Resonance

Surface Plasmon Resonance (SPR) is widely used in biological and chemical sensing with fascinating properties. However, the application of SPR to detect trace targets is hampered by non-specific binding and poor signal. A variety of approaches for amplification have been explored to overcome this deficiency including DNA aptamers as versatile target detection tools. Hybridization chain reaction (HCR) is a high-efficiency enzyme-free DNA amplification method operated at room temperature, in which two stable species of DNA hairpins coexist in solution until the introduction of the initiator strand triggers a cascade of hybridization events. At an optimal salt condition, as the concentrations of H1 and H2 increased, the HCR signals were enhanced, leading to signal amplification reaching up to 6.5-fold of the detection measure at 30 min. This feature enables DNA to act as an amplifying transducer for biosensing applications to provide an enzyme-free alternative that can easily detect complex DNA sequences. Improvement of more diverse recognition events can be achieved by integrating HCR with a phase-sensitive SPR (pSPR)-tested aptamer stimulus. This work seeks to establish pSPR aptamer system for highly informative sensing by means of an amplification HCR. Thus, combining pSPR and HCR technologies provide an expandable platform for sensitive biosensing

Microrna-486-5P Regulates Human Pulmonary Artery Smooth Muscle Cell Migration via Endothelin-1

Pulmonary arterial hypertension (PAH) is a fatal or life-threatening disorder characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance. Abnormal vascular remodeling, including the proliferation and phenotypic modulation of pulmonary artery smooth muscle cells (PASMCs), represents the most critical pathological change during PAH development. Previous studies showed that miR-486 could reduce apoptosis in different cells; however, the role of miR-486 in PAH development or HPASMC proliferation and migration remains unclear. After 6 h of hypoxia treatment, miR-486-5p was significantly upregulated in HPASMCs. We found that miR-486-5p could upregulate the expression and secretion of ET-1. Furthermore, transfection with a miR-486-5p mimic could induce HPASMC proliferation and migration. We also found that miRNA-486-5p could downregulate the expression of SMAD2 and the phosphorylation of SMAD3. According to previous studies, the loss of SMAD3 may play an important role in miRNA-486-5p-induced HPASMC proliferation. Although the role of miRNA-486-5p in PAH in in vivo models still requires further investigation and confirmation, our findings show the potential roles and effects of miR-486-5p during PAH development

Performance of algorithm A and B to screen gestational diabetes mellitus in the training cohort and in the validation cohort.

<p>Performance of algorithm A and B to screen gestational diabetes mellitus in the training cohort and in the validation cohort.</p

Pregnancy outcomes in women with and without gestational diabetes mellitus defined by algorithm A, B, or the IADPSG criteria.

<p>Pregnancy outcomes in women with and without gestational diabetes mellitus defined by algorithm A, B, or the IADPSG criteria.</p